Skip to main content
eRx

EPCS Quick Start: Controlled Substances

  • August 13, 2025
  • 0 replies
  • 168 views

Ensora Education Team
Forum|alt.badge.img

In order to send prescriptions for controlled substances to a pharmacy electronically, providers must register for Electronic Prescribing of Controlled Substances (EPCS). EPCS registration is a three-part process that providers can complete within the system. Use this checklist to get started.

 

NOTE: EPCS is optional and requires vendor certification.

 

newcrop_account_administrators.png

Assign EPCS administrators that will grant and revoke EPCS privileges for prescribers. You can set up multiple administrators. At least one administrator must have an active DEA number, and others can be any other kind of user (for example, a staff nurse or Advance Practice Practitioner).

newcrop_register_for_epcs.png

Providers who will need to prescribe controlled substances must complete the EPCS registration process. Providers will verify identity and set up two-factor authentication for transmitting controlled substance prescriptions. An EPCS account administrator will then confirm their registration in the system. 

newcrop_prescribe_cs.png

Once you have completed your EPCS registration, you will be able to prescribe controlled substances through the system using a two-factor authentication process.

newcrop_EPCS_account.png

It's a good idea to have more than one way to authenticate your prescriptions. Make sure you have activated both the hardware token and Authy app.

Add a NADEA (XDEA) Number to your account if you will be writing prescriptions that will require it.

Most of the time, prescribers will complete the identity proofing process online during EPCS registration. However, if necessary, there are alternate methods to verify your identity via snail mail or webcam.

This topic has been closed for replies.